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In particle physics, Fermi's interaction (also the Fermi theory of beta decay or the Fermi four-fermion interaction) is an explanation of the beta decay, proposed by Enrico Fermi in 1933. The theory posits four fermions directly interacting with one another (at one vertex of the associated Feynman diagram). This interaction explains beta decay of a neutron by direct coupling of a neutron with an electron, a neutrino (later determined to be an antineutrino) and a proton.
Fermi first introduced this coupling in his description of beta decay in 1933. The Fermi interaction was the precursor to the theory for the weak interaction where the interaction between the proton–neutron and electron–antineutrino is mediated by a virtual W− boson, of which the Fermi theory is the low-energy effective field theory.